Research

Three published papers.

One thesis.

From supercritical fluids in chemical physics to 3D self-supervised vision transformers at Harvard. Each paper, the journal, and a link.

BioRxiv2025

SpatialDINO: Self-Supervised Learning for 3D Vision Transformers

Arkash Jain et al. (Kirchhausen Lab, Harvard Medical School)

A 3D self-supervised vision transformer that beats a Nobel laureate-led approach for understanding subcellular structures from cryo-electron tomograms.

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Journal of Cell Biology2026

Close-up of Vesicular ER Exit Sites by Volume Electron Imaging using FIB-SEM

Kirchhausen Lab

Volumetric reconstruction of mammalian ER exit sites at unprecedented resolution via FIB-SEM and learned segmentation.

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Journal of Chemical PhysicsNov 2022

Ultrafast 2DIR comparison of rotational energy transfer, isolated binary collision breakdown, and near critical fluctuations in Xe and SF6 solutions

Arkash Jain et al.

First-author work on supercritical-fluid dynamics using ultrafast two-dimensional infrared spectroscopy.

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Infrastructure

The full ML stack

What it takes to train SpatialDINO end-to-end.

Training stack

  • › Infiniband / RDMA collective ops
  • › RAID storage tier with NVMe cache
  • › NVLink intra-node, DGX A100/H100 nodes
  • › PyTorch FSDP + bf16 mixed precision
  • › Activation checkpointing for large models

Open source

PyTorch Issue #144779

Diagnosed and reported a Rendezvous (RDZV) backend issue affecting Infiniband multi-node training; contributed reproduction steps and root-cause analysis.

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